Effect of Ursolic Acid of Loquat Extract on Function of Muscle

Pusan National University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Sarcopenia

Treatments: Dietary Supplement: UA group

Study type: Interventional

Funder types: Other

Identifiers

NCT02401113

UrsolicAcid

Details and patient eligibility

About

This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks.

Full description

This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks. Change over time in muscle fuction was evaluated by four outcomes: assessment of appendicular skeletal mass using DEXA (dual energy X-ray absorptiometry); quadriceps muscle power by Biodex; hand grib power; and Short Physical Performance Battery, SPPB.

Enrollment: 54 patients

Sex: All

Ages: 19 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 18.5-30KG/M2

Exclusion criteria

• > SERUM creatinine 1.2mg/dL
• > AST or ALT 60IU/L
• DM Patients

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

54 participants in 2 patient groups, including a placebo group

UA group

Experimental group

Description:

UA group who takes Ursolic acid of Loquat Extract , 500 mg/ day during 12 weeks for treatment of muscle function improvement with relatively health adults

Treatment:

Dietary Supplement: UA group

placebo group

Placebo Comparator group

Description:

placebo group who takes a placebo, 500 mg/day for 12 weeks

Treatment:

Dietary Supplement: UA group