Effect of Urtica Dioica on Glycemic Control in Patients With Type 2 Diabetes Mellitus

Shahid Beheshti University of Medical Sciences

Status and phase

Completed

Phase 1

Conditions

Type 2 Diabetes Mellitus

Treatments

Drug: Urtica Dioica (Tea bag)

Study type

Interventional

Funder types

Other

Identifiers

NCT00422357

NNFTRI-1385

Details and patient eligibility

About

Diabetes mellitus is the most common metabolic disorder worldwide. Some herbs are traditionally used in treatment of type 2 diabetes mellitus (T2DM). Urtica Dioica (UD) or stinging nettle is traditionally used in Morocco, Turkey, Brasil, Jordan and with much frequency in northern Iran.

Studies on animal models along with in vitro studies has shown hypoglycemic effect for aqueous extract of UD.

This study aimed to investigate hypoglycemic effects of UD tea bags in patients with T2DM on glycemic control, insulin sensitivity, along with its effects on lipid profile (LP), blood pressure (BP), liver, and kidney function.

Full description

The study will be performed under randomized, double-blind, placebo controlled, and case-control design. The object of this study is patients with T2DM. Patients are randomly assigned to start with placebo tea bags (3 tea bags as 2-gram tea bag steamed in boiling water for 20 minutes: mixture of bran powder which is already boiled in water twice plus spinach powder) in control groups and UD tea bags (3 tea bags as 2-gram tea bag steamed in boiling water for 20 minutes) in patients with T2DM for two months. Every two weeks, fasting glucose, postprandial glucose after a standard breakfast, serum insulin, lipids, alanine amino transferase (ALT), aspartate amino transferase (AST), creatinine (to calculate GFR), along with blood pressure will be measured.

To the best of our knowledge, this is the first Randomized Clinical Trial.

Sex

All

Ages

30+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Clinical diagnosis of T2DM
Must be able to drink UD or Placebo tea bags 3 times every day

Exclusion criteria

Insulin dependent diabetes
History of congestive heart failure within last 5 years (NYHA Class III-IV)
History of significant pulmonary disease, myocardial infarction, cerebrovascular accident, or nephrotic syndrome within last 1 year
Thyroid disease
Known renal or hepatic insufficiency
Gastric problem
History of UD or and other herb use in past 6 months
Pregnancy or lactation
Use of any herbal or supplement within past 6 months
Use of an investigational drug (within 30 days prior to enrollment)
Known maternal allergies
Dumping syndrome