Effect of Using Nanochitosan Versus Calcium Hydroxide as Disinfectant on Pain and Apical Bone Healing

Cairo University (CU)

Status

Unknown

Conditions

Postoperative Pain

Healing

Treatments

Drug: Calcium Hydroxide

Drug: Chitosan

Study type

Interventional

Funder types

Other

Identifiers

NCT03724266

ahmed abdelmonam

Details and patient eligibility

About

Effect of Using Nanochitosan versus Calcium Hydroxide as Intracanal Medications on the Postoperative Pain and Apical Bone Healing

Full description

PICO approach P (population): maxillary anterior teeth having necrotic pulp with symptomatic apical periodontitis with evidence of apical radiolucency (minimum size 2 mm x 2 mm).

I (intervention):0.2% nanochitosan as intracanal medication. C (control): calcium hydroxide paste intracanal medication.

O (outcome):

Primary outcome: postoperative pain at time interval 4, 12, 24, 48, 72 hours

Secondary outcome:

Postoperative pain, swelling, palpation, percussion and mobility at one week, 3, 6, 12 months
Number of analgesic tablets used at 4, 12, 24, 48, 72 hours and one week.
healing of apical periodontitis using CBCT at 3, 6, 12 months

Enrollment

60 estimated patients

Sex

All

Ages

20 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients in good general health.
Patient's age ranging between 20-40 years with no sex predilection.
Maxillary anterior teeth with non-vital pulp and symptomatic apical periodontitis.
Evidence of apical radiolucency (minimum size 2 mm x 2 mm).
Patients' acceptance to participate in the study.

Exclusion criteria

Medically compromised patients with a severe systemic condition.
Pregnant female patients.
Patients who had taken any antibiotic or analgesics during the past 24 hours.
Presence of a swelling because emergency management may include incision and drainage.
Retreatment cases.
Generalized periodontitis (calculus, deep pockets).
Out of normal variations (open apex- severely curved canal- obstructed canal).