Effect of Variable PSV in Acute Lung Injury: Part I and Part II

University of Genova

Status: Completed

Conditions: Acute Distress Respiratory Syndrome (ARDS); Acute Lung Injury (ALI)

Treatments: Other: Noisy-PSV 2; Other: Noisy-PSV 1

Study type: Interventional

Funder types: Other

Identifiers

NCT01683669

91/12

Details and patient eligibility

About

Noisy Pressure Support Ventilation (noisy-PSV) would lead to improved lung function, while preserving respiratory muscle unloading. Basically, noisy PSV differs from other assisted mechanical ventilation modes that may also increase the variability of the respiratory pattern (e.g. proportional assist ventilation) by the fact that the variability does not depend on changes in the patient's inspiratory efforts.

The aim of this study is to evaluate the optimal variability for noisy PSV in patients with ALI based on its effects on respiratory mechanics, breathing comfort, gas exchange, and hemodynamics. The investigators hypothesize that noise in pressure support leads to variations in VT that are able to improve lung function and that physiologic variables respond differently to the degree of variability in pressure support

Enrollment: 20 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Intubated/tracheostomized patients in assisted mechanical ventilation
• PaO2/FiO2 100-300, with PEEP ≥ than 5 cmH2O.

Exclusion criteria

• Pregnancy
• History of chronic lung disease (COPD)
• Presence of thoracic drainage

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Noisy-PSV 1

Other group

Description:

different levels of variable pressure support

Treatment:

Other: Noisy-PSV 1

Noisy-PSV 2

Other group

Description:

different levels of variable pressure support

Treatment:

Other: Noisy-PSV 2