Effect of Variance on Error Correction During Coupling

Hasselt University

Status: Completed

Conditions: Multiple Sclerosis; Progressive Multiple Sclerosis

Treatments: Other: synchronisation abilities

Study type: Interventional

Funder types: Other

Identifiers

NCT04856384

MS-Music-LM-001

Details and patient eligibility

About

This study is a case-control study, involving persons with progressive multiple sclerosis and healthy controls. The study contains 1 descriptive and 3 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, with period and phase auditory manipulations. In the latter twp sessions, apart from outcome measures of synchronization the following will be collected as well: brain activity using EEG recordings, spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.

Enrollment: 13 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diagnosis of Multiple sclerosis >1 year, diagnosis of progressive MS,
• walking speed 0.8-1.2m/s, ability to walk for 6 minutes continuously (canes and rollators are permitted)

Exclusion criteria

• relapse 3 months prior to enrollment,
• cognitive impairment impeding understanding of instructions,
• beat amusia,
• deafness,
• pregnancy

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Parallel Assignment

Masking: None (Open label)

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13 participants in 2 patient groups

persons with Multiple Sclerosis

Experimental group

Treatment:

Other: synchronisation abilities

Healthy controls

Experimental group

Treatment:

Other: synchronisation abilities