Effect of Various Sealers on Healing of Teeth With Apical Periodontitis

Postgraduate Institute of Dental Sciences Rohtak

Status: Completed

Conditions: Apical Periodontitis

Treatments: Procedure: Zinc oxide based sealer; Procedure: Bioactive silicone based sealer; Procedure: Epoxy resin based sealer

Study type: Interventional

Funder types: Other

Identifiers

NCT03397875

Aparna Tripathi

Details and patient eligibility

About

This study will compare the effect of three different sealers on healing of teeth with apical periodontitis after primary root canal treatment.

Full description

Various sealers with different chemical composition and properties are available but it is yet not clear if one sealer is superior to other in terms of healing of apical periodontitis.

Three different groups of sealers will be used- a zinc oxide based sealer, an epoxy resin based sealer and a bioactive silicone based sealer. Mature mandibular permanent molar with the diagnosis of apical periodontitis (as confirmed clinically & by periapical radiograph) will be chosen for the study. Primary non surgical root canal treatment will be performed. The sealer will be randomly selected just before obturation of root canals. The patient will be allotted to one of the three groups.

• Group I: Zinc oxide eugenol sealer group. The material will be mixed according to manufacturer instructions and applied to canals using a lentulospiral and the obturation will be performed.
• Group II: Epoxy resin based sealer group. The material will be mixed according to the manufacturer's instructions and obturation will be done.
• Group III: Bioactive silicone based sealer: The material will be used according to the manufacturer's instruction and obturation will be performed

Enrollment: 99 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

The inclusion criteria of the study will include:

• Patient willing to participate in the study.
• Age >18 years.
• No history of antibiotic use within the past month or requiring antibiotic premedication
• No history of prior analgesic use during past 24 hrs.
• Mature permanent mandibular molar having apical periodontitis requiring primary root canal treatment.
• There must be a radiographic evidence of periapical radiolucency (minimum size 2mmx2mm) and a diagnosis of pulpal necrosis, as confirmed by negative response to cold and electrical tests; and absence of bleeding on entering the pulp chamber

Exclusion criteria

• Re-treatment
• Unwillingness of patients
• The presence of a difficult canal anatomy (root canals with an extreme curvature ≥30 deg), internal or external resorption and immature teeth.
• Accident or complication during treatment (calcified canals ,inability to achieve apical patency in any canals) Immuno-compromised, diabetic, pregnant and hypertensive patients.
• Teeth that are peridontally compromised

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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99 participants in 3 patient groups

Zinc oxide based sealer

Active Comparator group

Description:

After root canal treatment obturation with gutta percha will be done using zinc oxide based sealer.

Treatment:

Procedure: Zinc oxide based sealer

Epoxy resin based sealer

Experimental group

Description:

After root canal treatment obturation with gutta percha will be done using epoxy resin based sealer.

Treatment:

Procedure: Epoxy resin based sealer

Bioactive silicone based sealer

Experimental group

Description:

After root canal treatment obturation with gutta percha will be done using bioactive silicone based sealer.

Treatment:

Procedure: Bioactive silicone based sealer