Effect of Vegetation in Kindergartens on the Immune Response of Children (ADELEWP1t7)

University of Helsinki

Status: Unknown

Conditions: Ige Responsiveness, Atopic

Treatments: Other: Adding of vegetation into the backyards of kindergarten

Study type: Interventional

Funder types: Other

Identifiers

NCT02733926

HelsinkiU1

Details and patient eligibility

About

This study evaluates the effect of vegetation cover on certain Interleukin-10 and immunoglobulinE (IgE) among children (3-5 y old). Children will either be in a kindergarten that does not have forest floor and agricultural land in the backyards, or alternatively they will be in a kindergarten that does have forest floor and agricultural land in the backyards.

Full description

High vegetation cover is assumed to change immunoglobulinE (IgE) and interleukin-10 concentrations in blood serum. Children living in high-green kindergarten are compared with those kindergarten living utilizing backyards with a low-green cover.

Enrollment: 100 estimated patients

Sex: All

Ages: 3 to 5 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• children living in study kindergartens

Exclusion criteria

• immune system deficiency, e.g. HIV-infection
• a drug decreasing immune system response, e.g. oral corticosteroid
• immune system disorder that affects immune response, e.g. rheumatoid
• colitis ulcerosa, Crohn disease, diabetes
• cancer
• age less than 3 or more than 5
• born outside Finland
• intellectual disability

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 3 patient groups

City kindergarten

No Intervention group

Description:

Children living in a normal city kindergarten that hardly has vegetation in backyards

adding of vegetation into the backyards.

Experimental group

Description:

Children living in a normal city kindergarten that has plenty of vegetation in backyards. Intervention: adding of vegetation into the backyards.

Treatment:

Other: Adding of vegetation into the backyards of kindergarten

Nature kindergarten

No Intervention group

Description:

Children living in a city kindergarten where children go regularly into a natural forest