Effect of Ventilation Mode on Lung Deposition of a Radiolabeled Aerosol During Mechanical Ventilation: Barometric Versus Volumetric

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Completed

Conditions: Post-operative Neurosurgery

Treatments: Drug: technetium-99m - Diethylenetriaminepentaacetic acid; Other: Preoperative spirometry; Device: Vibrating-mesh nebulizer; Other: Gamma scintigraphy

Study type: Interventional

Funder types: Other

Identifiers

NCT01879488

AeroVent-01

Details and patient eligibility

About

Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization. No studies looked into conditions of nebulization during assisted mechanical ventilation to define the optimal nebulization technique and its effect on pulmonary deposition.

The aim of this study is to analyse the effect of ventilation mode (barometric versus volumetric) on deposition by planar scintigraphy during mechanical ventilation.

Enrollment: 19 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Invasive mechanical ventilation
• Healthy lungs

Exclusion criteria

• Change of ventilation mode during nebulization

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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19 participants in 2 patient groups

Nebulization during pressure support ventilation

Active Comparator group

Description:

Patients ventilated in pressure support mode during nebulization

Treatment:

Drug: technetium-99m - Diethylenetriaminepentaacetic acid

Other: Preoperative spirometry

Other: Gamma scintigraphy

Device: Vibrating-mesh nebulizer

Nebulization during volume assist control mode

Active Comparator group

Description:

Patients ventilated in volume assist control mode during nebulization

Treatment:

Drug: technetium-99m - Diethylenetriaminepentaacetic acid

Other: Preoperative spirometry

Other: Gamma scintigraphy

Device: Vibrating-mesh nebulizer