Effect of Vit D on New-onset AF in Hypertension

Ankara University

Status: Completed

Conditions: Hypertension; Atrial Fibrillation

Study type: Observational

Funder types: Other

Identifiers

NCT02298738

AnkaraU

Details and patient eligibility

About

Atrial fibrillation (AF), an important cause of cardiac mortality and morbidity is the most common type of cardiac arrhythmia in clinical practice. Hypertensive individuals are at particular risk of development of atrial fibrillation. Renin-angiotensin-aldosteron system (RAS) which is activated in hypertension may be the underlying mechanism of AF among hypertensive patients.

Vitamin D deficiency has been shown to be involved in the pathogenesis of hypertension, cardiovascular disease and obesity. Increased RAS activity is one of the postulated mechanisms by which vitamin D deficiency may trigger the development of hypertension and various cardiovascular diseases. On the basis of these data we hypothesized that hypovitaminosis D might be associated with new-onset AF among patients with hypertension.

Enrollment: 227 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hypertensive patients with new-onset AF

Exclusion criteria

Established coronary artery disease

• Heart failure
• Chronic obstructive pulmonary disease
• Diabetes mellitus
• Significant heart valve disease
• Hyperthyroidism
• Renal failure
• Any malignancy
• Acute infection
• Recent thoracic or abdominal surgery
• Under therapy of Vit D3

Trial design

227 participants in 2 patient groups

New onset Atrial fibrillation

Description:

New-onset AF was defined as patients with hypertension and atrial fibrillation which was identified for the first time by an electrocardiogram or ambulatory holter monitoring.

control

Description:

Hypertensive patients without atrial fibrillation.