Effect of Vitamin A Supplementation on Iron Metabolic Homeostasis of Preschool Children in Sichuan,China

Chengdu Maternal and Children's Health Care Hospital

Status: Completed

Conditions: Iron Metabolic Homeostasis

Treatments: Drug: iron and vitamin a

Study type: Interventional

Funder types: Other

Identifiers

NCT01355263

20090221

Details and patient eligibility

About

The investigators plan to perform a randomized, mutual-control and double-blinded cohort study to further exploit the vitamin A supplementation on iron metabolic homeostasis (including iron reserve, mobilization and absorption status in the same population) compared with solely iron and vitamin A plus iron.

Enrollment: 450 patients

Sex: All

Ages: 2 to 6 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• apparent health;
• Hb concentration>60 g/L;
• C-reaction protein (CRP)<10 mg/L;
• parental or guardian approval of participation in all aspects of the study; and
• parental/guardian agreement to avoid the additional use of vitamin and mineral supplements during the investigation.

Exclusion criteria

• does not match the inclusion criteria

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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450 participants in 1 patient group

iron tablet, vitamin a capsule

Experimental group

Description:

children in Group I received a 200,000 IU vitamin A capsule just one time initially; Group II received ferrous sulfate (element Fe 1-2 mg/kg•day) once a day for 6 months;.

Treatment:

Drug: iron and vitamin a