Effect of Vitamin D Deficiency and Vitamin D Supplementation on Glucose Metabolism
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About
This study was intended to evaluate the effect of vitamin D supplementation on insulin sensitivity and pancreatic islet beta-cell function. Our hypothesis was that vitamin D supplementation to normal levels in patients with impaired fasting glucose will result in improved insulin sensitivity and improved beta cell function.
Full description
A modified frequently sampled intravenous glucose tolerance (mFSIGT) test was used. On day 0, baseline 22 time point mFSIGT was performed. Subjects were then treated with cholecalciferol (vitamin D3) supplementation - 10,000 IU/day - for 28 consecutive days. mFSIGT was then repeated measuring glucose, insulin and c-peptide at all time points. 25-OH vitamin D, PTH, and calcium were also measured at time point 0 pre and post vitamin D supplementation. Data was analyzed using the Bergman/Boston minimal model for insulin homeostasis with MinMod Millennium software.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Impaired fasting glucose
- Adult, age between 18 and 65
- Serum vitamin D level below 30 ng/mL
Exclusion criteria
- History of nephrolithiasis
- Any medications that can effect insulin sensitivity or beta cell function (i.e. antipsychotics, metformin)
- Pregnancy
- Liver disease
- Renal disease
Trial design
Primary purpose
Allocation
Interventional model
Masking
12 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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