Effect of Vitamin D Supplementation on Hemoglobin A1c in Patients With Uncontrolled Type 2 Diabetes Mellitus

ProMedica Health System

Status: Completed

Conditions: Type 2 Diabetes Mellitus

Treatments: Dietary Supplement: Vitamin C 500mg daily; Dietary Supplement: Vitamin D3 2000 international units daily

Study type: Interventional

Funder types: Other

Identifiers

NCT00985361

09-055

Details and patient eligibility

About

The purpose of this study is to determine if daily supplementation with 2000 International Units of Vitamin D will improve hemoglobin A1c in uncontrolled type 2 diabetics.

Full description

Vitamin D is typically understood to support musculoskeletal health when administered concomitantly with calcium. A number of recent studies suggest, however, that this important nutrient may play a significant role in many pathophysiological processes, including diabetes mellitus. With the prevalence of diabetes mellitus ever increasing, novel mechanisms for controlling blood glucose and hemoglobin A1c are being sought to help prevent the costly and debilitating complications of this chronic disease.

Enrollment: 37 patients

Sex: All

Ages: 21 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetes mellitus
• Hemoglobin A1c >7% measured in the 3 months prior to randomization
• Age 21 to 75 years

Exclusion criteria

• Renal insufficiency (defined as CrCl <30mL/min)
• Gestational diabetes
• Malabsorption syndrome
• Patients taking vitamin D supplements at doses >400 international units daily

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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37 participants in 2 patient groups

Vitamin D 2000 international units daily

Experimental group

Treatment:

Dietary Supplement: Vitamin D3 2000 international units daily

Vitamin C 500mg daily

Active Comparator group

Treatment:

Dietary Supplement: Vitamin C 500mg daily