Effect of Vitamin D Supplementation on Metabolic Parameters of Patients With Psoriasis

Pontificia Universidad Catolica de Chile

Status: Completed

Conditions: Psoriasis; Vitamin D Deficiency; Metabolic Syndrome

Treatments: Dietary Supplement: Vitamin D3; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02271971

14-412

Details and patient eligibility

About

The purpose of this study is to determine whether supplementation with oral vitamin D (cholecalciferol) improves metabolic parameters in patients with moderate to severe psoriasis.

Enrollment: 39 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of moderate to severe psoriasis.
• Being treated with methotrexate with stable doses for al least 1 month.

Exclusion criteria

• Phototherapy within the past 2 months.
• History of psoriatic arthritis, rheumatoid arthritis, type 1 diabetes mellitus or inflammatory bowel disease.
• Use of vitamin d supplements or fish oil supplements in the past 2 months.
• Use of hypolipidemic drugs, hypoglycemic drugs, glucose sensitizers, oral corticosteroids, orlistat, cholestyramine, phenobarbital or phenytoin within the past 2 months.
• Pregnancy or lactation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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39 participants in 2 patient groups, including a placebo group

Vitamin D3 supplementation

Experimental group

Description:

Subjects in the experimental arm will receive a daily 5.000 IU vitamin D3 capsule during 6 weeks.

Treatment:

Dietary Supplement: Vitamin D3

Placebo

Placebo Comparator group

Description:

Subjects in the placebo arm will receive a daily placebo capsule during 6 weeks.

Treatment:

Dietary Supplement: Placebo