Effect of Vitamin D3 on Cardiovascular Risk Factors

Martin-Luther-Universität Halle-Wittenberg

Status: Completed

Conditions: Hypertensive Disease; Deficiency of Vitamin D3

Treatments: Dietary Supplement: Vitamin D3; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01501916

0315668A

Details and patient eligibility

About

The aim of this study is to investigate whether a supplementation of Vitamin D3 can be used to reduce atherosclerotic risk factors.

Full description

It is the objective of this study to investigate whether a supplementation with Vitamin D3 can be used to reduce atherosclerotic risk factors such as hypertension, inflammation and hyperlipidemia. The research question is whether Vitamin D3 can lower blood pressure in mildly hypertensive subjects who are naive to antihypertensive medication, whether Vitamin D reduces the level of systemic inflammation and whether Vitamin D3 has an effect on blood lipids.

major outcomes:

• decrease of systolic blood pressure in the treatment group in comparison with the placebo group

Enrollment: 250 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• human volunteers with mild hypertension

Exclusion criteria

• use of antihypertensive medication
• use of vitamin d or calcium supplements
• known renal, inflammatory or malignant diseases
• hypercalcemia or hypercalciuria
• participation in other clinical studies
• use of tanning booths during the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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250 participants in 2 patient groups, including a placebo group

vitamin d

Experimental group

Treatment:

Dietary Supplement: Vitamin D3

Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo