Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension

Tehran University of Medical Sciences

Status and phase: Unknown; Phase 2

Conditions: Acute Kidney Injury

Treatments: Drug: vitamin E +Selenium

Study type: Interventional

Funder types: Other

Identifiers

NCT01554345

89-04-30-11624

Details and patient eligibility

About

The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it

Full description

NGAL(Neutrophil Gelatinase Associated Lipocalin) is a 25KD protein which bounds with Gelatinase in Neutrophil granules.It is also expressed in epithelial cells of kidney tubules.NGAL increases in ischemic and toxic injuries of kidney. During controlled hypotension in brain operations injury to the kidneys might occur . This study is designed to assess this possibility and evaluate the effect of VitaminE+Selenium on prevention of this problem

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All patients who are candidate for brain surgery under controlled hypotension

Exclusion criteria

• Positive history of renal disease
• Positive history of diabetes mellitus, CHF, HTN, Breast cancer, fever, leukocytosis

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind