Effect of Vitis Vinifera Extract on Oxidative Stress, Inflamatory Biomarkers and Hormones in High Trained Subjects

Rio de Janeiro State University

Status: Unknown

Conditions: Athletic Injuries

Treatments: Dietary Supplement: grape fruit (vitis vinifera) extract in capsule with 205 mg

Study type: Interventional

Funder types: Other

Identifiers

NCT01875497

E26-103.011/2012

Details and patient eligibility

About

There is evidence that intense physical activity has a potential effect on thrombotic events due to catecholamine release. The hormones leptin and adiponectin have been used as markers of cardiovascular risk, but they are few and contradictory studies that relate physical training intensity and duration of high plasma concentrations of these hormones. The use of antioxidants, such as proanthocyanidins present in grapes, may help in reducing the undesirable effects of intense training.

Full description

Fifty four Brazilian healthy military without hyperglycemia, diabetes mellitus and endocrine disease were enrolled in this study. All subjects were high physically military trained. The Ethical Committee of the Universidade do Estado do Rio de Janeiro in Brazil (COEP008/2011) approved the study protocol. Informed consent was obtained from each subject after explanation of purpose and risks of all procedures used.

Enrollment: 55 estimated patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy physically active men

Exclusion criteria

• Diabetes, hypertension, obesity subjects, drug use

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Double Blind

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55 participants in 1 patient group

Dietary Supplement

Experimental group

Description:

Before the exercise, the individuals intake only one capsule with 205 mg of the grape fruit extract in capsule with 205 mg.

Treatment:

Dietary Supplement: grape fruit (vitis vinifera) extract in capsule with 205 mg