Effect of Water Exchange Plus Acetic Acid Staining on the Detection of Flat Polyps During Colonoscopy

Air Force Military Medical University of People's Liberation Army

Status: Unknown

Conditions: Adenoma Colon

Treatments: Other: acetic acid staining; Other: Water exchange colonoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT04464135

KY20200706-3

Details and patient eligibility

About

Our previous study (Am. J. Gastroenterol. 2017 04;112(4)) showed that water exchange (WE) colonoscopy was able to increase the detection of flat adenomas as well as overall ADR. We hypothesized that WE based whole-colon acetic acid（AA） staining might be useful to improve the detection of flat lesions compared with WE alone.

Full description

Water exchange colonoscopy was performed as described previously (Am. J. Gastroenterol. 2017 04;112(4)). Patients were randomly allocated to WE group or WE+AA group. In WE+AA group, water containing 1% of AA was used during insertion of colonoscopy instead of water alone. A bottle of 20ml pure AA was placed abutting the water pump, which make it possible to keep patients blinded to group allocation. Endoscopist using a high-definition wide-angle Olympus or Fujinum colonoscope performed all of the colonoscopies, with a withdrawal time of at least 6 min. The observation was initially performed without the assistance of cap or the use of magnification or electronic staining (NBI, BLI, LCI or AFI et al.). Scopolamine butylbromide or glucogon was not routinely administrated.

Enrollment: 300 estimated patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 40-70
• Undergoing colonoscopy after standard bowel preparation

Exclusion criteria

• Known familial polyposis
• Small amount of feces or semi-solid stool in last rectal effluent
• Inflammatory Bowel Disease
• Lactated or pregnant women
• Unable to provide informed content

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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300 participants in 2 patient groups

WE+AA group

Experimental group

Description:

Water containing 1% of AA was used during insertion of colonoscopy using water exchange method.

Treatment:

Other: acetic acid staining

WE group

Active Comparator group

Description:

Water exchange colonoscopy was used for standard screening or surveillance colonoscopy.

Treatment:

Other: Water exchange colonoscopy