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Effect of Water Intake and Water Restriction on Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease

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Rigshospitalet

Status

Completed

Conditions

ADPKD

Treatments

Other: water

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The objective of this study is to measure the influence of both short term water restriction and high water intake on total kidney volume, measured by Magnetic Resonance Imaging (MRI) scan in Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients.

Full description

Patients will be randomized to either water restriction for 3 hours or high water intake (20 ml/kg) for 1 hour. Before intervention and after intervention patients will have an MRI scan of the kidneys to measure the total kidney volume (TKV) (differentiated in cortex, medulla and cyst volume). The objective is to identify whether water restriction or high water load will change the TKV. Secondly investigators will analyze different biomarkers (aldosterone, renin, vasopressin/copeptin, urine- and blood-osmolarity) before and after the intervention.

Enrollment

40 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ADPKD
  • CKD stage 1-3

Exclusion criteria

  • Patients treated with diuretics
  • Pregnancy
  • Change in antihypertensive treatment < 1 month
  • Any condition contraindicating MR scan

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

40 participants in 2 patient groups

water restriction
No Intervention group
Description:
20 patients will be subjected to 3 hours of water restriction following MR scan of the kidneys.
high water intake
Active Comparator group
Description:
20 patients will be subjected to 1 hour of high water intake (20 ml/kg) following MR scan of the kidneys.
Treatment:
Other: water

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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