Effect of Weight Loss on Myocardial Metabolism and Cardiac Relaxation in Obese Adults

The Washington University

Status: Completed

Conditions: Obesity

Treatments: Behavioral: Diet; Procedure: Gastric bypass surgery

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00572624

05-0523 (201105066)

P01HL013851-43 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Obesity adversely affects myocardial (muscular heart tissue) metabolism, efficiency, and diastolic function. The objective of this study was to determine if weight loss could improve obesity-related myocardial metabolism and efficiency and if these improvements were directly related to improved diastolic function.

Full description

This was a prospective, interventional study in obese adults ages 21 to 50 years of age to determine whether weight loss could improve obesity-related myocardial metabolism and efficiency. Two different mechanisms of weight loss were studied: diet and exercise and gastric bypass surgery. Positron emission tomography (PET) was used to quantitate myocardial oxygen consumption (MVO2) and myocardial fatty acid (FA) metabolism. Echocardiography with tissue Doppler imaging was used to quantify cardiac structure, systolic and diastolic function (left ventricular (LV) relaxation (E') and septal ratio (E/E')).

Enrollment: 51 patients

Sex: All

Ages: 21 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index (BMI) > 30 kg/m^2
• Sedentary lifestyle

Exclusion criteria

• Body weight >159 kg
• Insulin-requiring diabetes
• Heart failure
• History of coronary artery disease
• Chest pain
• Untreated sleep apnea
• Being an active smoker
• Pregnant, lactating, or postmenopausal

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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51 participants in 2 patient groups

Diet

Experimental group

Description:

Participants who received counseling and instruction about weight loss through diet and exercise

Treatment:

Behavioral: Diet

Gastric bypass surgery

Experimental group

Description:

Participants who received gastric bypass surgery

Treatment:

Procedure: Gastric bypass surgery