Effect of Weight Reduction on Immunity

Shiraz University of Medical Sciences

Status and phase: Completed; Phase 3

Conditions: Anti-obesity Agents; Weight Loss; Lymphocytes; Immunity; Viral Diseases

Treatments: Combination Product: weight loss program

Study type: Interventional

Funder types: Other

Identifiers

NCT03336086

900413

Details and patient eligibility

About

This study included two groups of premenopausal healthy obese women. Experimental group underwent a weight loss program involved a low calorie diet plus anti-obesity drugs and moderate physical activity and control group underwent an ad libitum diet. At baseline and after a 10-15% weight loss lymphocyte subgroups were analyzed and compared between two group.

Full description

TCD3 and NKC CD16/56 were decreased significantly. Hence this weight loss program impaired viral immunity

Enrollment: 29 patients

Sex: Female

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI >=30
• female
• healthy
• no smoking
• not lactating
• not pregnant
• no medication use

Exclusion criteria

• pregnancy
• any disease
• any medication use
• iron and zinc deficiency
• any supplement use

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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29 participants in 2 patient groups

experimental

Other group

Description:

This group underwent a weight loss program

Treatment:

Combination Product: weight loss program

control

No Intervention group

Description:

This group underwent adlibitum diet + physical activity