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Participants will be randomly allocated to either Yakult ingestion or a control group. For the first 20 days, subjects will consume their normal diet (keeping a detailed food diary throughout). On days 21-28 they will switch to a high-fat/high-calorie diet.
The investigators hypothesise that consuming a high-fat, high-energy diet for 7 days will alter the composition of the gut microbiota and induce metabolic endotoxaemia / systemic inflammation as well as decreasing whole body insulin sensitivity (as we have shown previously). In contrast, the investigators hypothesise that consuming Yakult for 21 days before and 7 days throughout the high-fat diet will maintain a favourable gut microbiota and prevent metabolic endotoxaemia / systemic inflammation and thus maintain insulin action / insulin sensitivity.
Enrollment
Sex
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Volunteers
Inclusion criteria
Males and females
Aged 18-30
Physically active (exercising at least 3 times per week for more than 30 min at a time)
Non-smoker
Free from cardiovascular or metabolic disease
Weight stable for at least 6 months
Normal body mass index (BMI: 18.5-24.9 kg/m2)*
Compliant (i.e. understands and is willing, able and likely to comply with all study requirements)
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
56 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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