Effect of Yellow-Tinted Intraocular Lens on Standard Automated Perimetry (SAP) and Short-wavelength Automated Perimetry (SWAP) in Patients With and Without Glaucoma

Rassoul Akram Hospital

Status: Completed

Conditions: Cataract; Glaucoma

Treatments: Procedure: Phacoemulsification with yellow-tinted intraocular lens

Study type: Interventional

Funder types: Other

Identifiers

NCT01305616

975

Details and patient eligibility

About

To investigate the effect of yellow-tinted IOLs on the Short Wave-length Automated Perimetry (SWAP) and Standard Automated Perimetry (SAP) in patients with and without glaucoma.

Full description

Glaucoma is mostly a disease of old people and is highly accompanied with cataract.Some of these patients may need to perform cataract surgery during the course of glaucoma. But in glaucoma patients, the effect of cataract surgery and/or type of implanted intraocular lens (IOL) on the results of specific visual field tests, like SWAP, is still not well studied.From the past decade, various yellow-tinted IOLs with the speculation of protecting the retinal photoreceptors and decreasing the incidence of age-related macular degeneration have been introduced.These blue-light-filtering IOLs contain a yellow chromophore that filters ultra violet (UV) and a larger part of the high-energetic visible blue-light between 380 and 500 nm. Based on previous studies yellow-tinted IOLs decrease the amount of light transmission to the retina which may theoretically affect perimetry results. This might be even more important in patients with glaucoma where the sensitivity of test locations has decreased per se.

Since early diagnosis of glaucoma and its progression is highly dependent on visual field results, it is important to evaluate the effect of these IOLs on perimetry, particularly on SWAP, in which the blue-light-filtering IOLs might interfere with its findings.

Enrollment: 34 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• In group 1, visually significant cataract associated with well controlled mild to moderate open angle glaucoma (intraocular pressure < 18 with maximally-tolerated medical treatment)and no history of previous intraocular surgeries
• In group 2- Normal ophthalmic examination other than visually significant cataract

Exclusion criteria

• Diabetes mellitus
• neurological disease which may affect the results of visual field
• known systemic medication with involvement on visual field
• spherical refractive error less than -5 and more than +5 diopter
• cylindrical correction more than 3 diopter

Trial design

34 participants in 2 patient groups

Group 1, glaucoma and cataract

Active Comparator group

Description:

Group1 were those patients with visually significant cataract (less than grade 2) and mild to moderate open angle glaucoma

Treatment:

Procedure: Phacoemulsification with yellow-tinted intraocular lens

Procedure: Phacoemulsification with yellow-tinted intraocular lens

Group2, cataract patients

Sham Comparator group

Description:

This group included those patients with visually significant cataract and normal other eye examination.

Treatment:

Procedure: Phacoemulsification with yellow-tinted intraocular lens

Procedure: Phacoemulsification with yellow-tinted intraocular lens