Effect of Yohimbine on Colon Transit

Mayo Clinic

Status and phase

Completed

Phase 2

Phase 1

Conditions

Healthy Volunteers

Treatments

Drug: Yohimbine, oral

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00217048

275-05

Details and patient eligibility

About

This study is being done to learn if yohimbine, a naturally occurring drug, affects the speed at which food travels through the stomach, intestines and colon, and if yohimbine affects the amount of liquid you can drink in a short period of time. Understanding how yohimbine works on the gut may help develop new treatments for patients with constipation. Yohimbine has been approved by the Food and Drug Administration (FDA) for routine clinical use, however, its use as proposed in this study is considered investigational.

Enrollment

30 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Healthy male or non-pregnant, non-breastfeeding female volunteers, -18-65 years old;
Able to provide written informed consent before participating in the study;
Able to communicate adequately with the investigator and to comply with the requirements for the entire study.