Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy (T2DMRS)

xiaolong zhao

Status and phase: Unknown; Phase 4

Conditions: Type 2 Diabetes

Treatments: Drug: Metformin; Drug: Exenatide

Study type: Interventional

Funder types: Other

Identifiers

NCT02129985

HS2014-005

Details and patient eligibility

About

Whether GLP-1 receptor agonists sequential therapy in newly diagnosed type 2 diabetic patients can further improve glycemic control, diabetes remission rate and β-cell function after the short-term insulin intensive therapy.

Full description

The UK Prospective Diabetes Study has shown that β-cell function progressively deteriorates over time in people with type 2 diabetes mellitus,irrespective of lifestyle and existing pharmacological interventions. The progressive nature of type 2 diabetes is one of the major challenges in the treatment of affected patients, and agents that could alter the natural history of this condition would add greatly to current treatment approaches.Short-term intensive insulin therapy of newly diagnosed type 2 diabetes has been proved improving beta-cell function and usually leading to a temporary remission time,but the remission rate in a year is only about 50%. The effect of GLP-1 receptor agonists on beta-cells is stimulation of glucose-dependent insulin release, followed by enhancement of insulin biosynthesis. It is stimulating beta-cell proliferation, induction of islet neogenesis, and inhibition of ß-cell apoptosis. Exenatide is an GLP-1 receptor agonist. Exenatide exerts direct effects on β-cell, which indicates that may contribute to delay disease progression. However, no study has evaluated effect of short-term intensive insulin sequential exenatide therapy model on β-cell function and glycemic remission rate in newly diagnosed type 2 diabetic patients. Our hypotheses is whether GLP-1 receptor agonists sequential therapy in newly diagnosed type 2 diabetic patients can further improve glycemic control, diabetes remission rate and β-cell function after the short-term insulin intensive therapy.

Enrollment: 100 estimated patients

Sex: All

Ages: 25 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• newly diagnosed type 2 diabetes without drug treatment
• 25-70 years old age
• Fasting glucose between 7.0-16.7mmol / L
• BMI at 20 ~ 35 kg/m2 and stable for at least 3 month(weight fluctuations within three months does not exceed 10%)
• females who have no plan of pregnancy during the study

Exclusion criteria

• acute or chronic complications of diabetes
• myocardial infarction or cerebrovascular events within three months
• serious gastrointestinal diseases
• other serious concomitant diseases
• liver or kidney dysfunction:Transaminase (ALT and AST) greater than 3 times the upper limit of the normal range or creatinine levels greater than 133μmol / L
• GAD antibodies positive
• history of pancreatitis or pancreatic cancer;
• pregnant or breastfeeding women.
• severe hypertension (blood pressure> 180/110mmhg)
• using corticosteroids, immunosuppressants and cytotoxic therapy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Exenatide

Experimental group

Description:

patients were all received a short-term intensive insulin therapy,then randomised to Exenatide group(10 ug two times a day for three months)

Treatment:

Drug: Exenatide

Metformin

Active Comparator group

Description:

patients were all received a short-term intensive insulin therapy,then randomised to metformin group(850mg two times a day for three months)

Treatment:

Drug: Metformin