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Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Double-lumen Endobronchial Intubation

J

Jeju National University School of Medicine

Status

Unknown

Conditions

Intubation, Intratracheal

Treatments

Drug: Remifentanil

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The purpose of this study is the comparison of the effect-site concentration of remifentanil for blunting hemodynamic responses to ordinary tracheal and double-lumen endobronchial intubation during propofol-remifentanil total intravenous anesthesia.

Enrollment

50 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adult patient who is needed intubation for general anesthesia

Exclusion criteria

  • patient who is anticipating difficult airway
  • patient who takes any drug to influence this study
  • cardiovascular disease, renal disease, liver disease

Trial design

Primary purpose

Prevention

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

50 participants in 2 patient groups

Double lumen tube
Experimental group
Description:
This arm contains patients who are needed endobronchial intubation with double lumen tube for general anesthesia. After propofol infusion of effect site concentration 4 μg/ml, remifentanil infusion will be started with effect site concentration of 3.5 ng/ml. According to change arterial blood pressure and heart rate from baseline value, next remifentanil concentration will be regulated using up-and-down method. Step size of dose is 0.5 ng/ml.
Treatment:
Drug: Remifentanil
single lumen tube
Active Comparator group
Description:
This arm contains patients who are needed endotracheal intubation with single lumen tube for general anesthesia. After propofol infusion of effect site concentration 4 μg/ml, remifentanil infusion will be started with effect site concentration of 3.5 ng/ml. According to change arterial blood pressure and heart rate from baseline value, next remifentanil concentration will be regulated using up-and-down method. Step size of dose is 0.5 ng/ml.
Treatment:
Drug: Remifentanil

Trial contacts and locations

1

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Central trial contact

Hyun Jung Kim, MD, PhD

Data sourced from clinicaltrials.gov

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