Effectiveness and Safety of Breeded Leech for Symptomatic Primary Arthrosis of the First Carpometacarpal Joint

Charité University Medicine Berlin

Status

Terminated

Conditions

Rhizarthrosis

Treatments

Biological: Leeches

Drug: Diclofenac

Study type

Interventional

Funder types

Other

Identifiers

NCT03020368

Leeches for Rhizarthrosis

Details and patient eligibility

About

In this trial the investigators want to prove the efficacy and safety of a one-time topical leech application at patients with symptomatic primary arthrosis of the first carpometacarpal joint in comparison to the standard therapy with topical diclofenac.

Enrollment

52 patients

Sex

All

Ages

35 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male and female patients aged 35 to 85 years
Pain intensity in the region of the thumb base in pain phases ≥ 40 mm on the VAS of 0 to 100 mm (relative to the last 24 hours)
Complaints for at least 3 months
X-ray Stadium Eaton I-IV at least once secured

Exclusion criteria

Anticoagulation (Marcumar, Heparin)
Haemophilia, V. Willebrandt Jürgens syndrome, thrombocytopathy and other blood anomalies
Combination therapy of ASA and thienopyridines
Pain medication with opioid analgesics
Systemic medication with corticoids or immunosuppressants
Intraarterticular injections or RSO within the last 3 months
Past or planned surgery on the affected joint in the next 2 months
Pregnancy, lactation
Insulin-dependent type I diabetes mellitus
Acute psychotic disorders
Severe comorbidity