Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From Cerebral Hemorrhage

Fudan University

Status and phase

Unknown

Phase 3

Phase 2

Conditions

Cerebral Hemorrhage

Lung Infection

Pneumonia

Treatments

Drug: rhubarb

Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT00815737

rhubarb cerebral hemorrhage

Details and patient eligibility

About

This study will determine if rhubarb will reduced the incidence of pneumonia and improved recovery from an acute cerebral hemorrhage. The study is designed to look at both infection rate and overall recovery and recovery of motor function, for example muscle strength and coordination.

Enrollment

100 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Occurrence of an acute cerebral hemorrhage (between 9 and 72 h after onset) with a score of at least 6 on the National Institute of Health Stroke Scale (NIHSS), and patient age of at least 18 years.
Have no pneumonia according to modified criteria of the U.S. Centers for Disease Control and Prevention (CDC)
Consistent with the Constipation of Phlegm-Heat Accumulation type by Traditional Chinese Medicine (TCM) standard
Patients or their representatives voluntarily take part in this study and signed the informed consent

Exclusion criteria

Cerebral infarction, transient ischemic attack(TIA)
Subarachnoid hemorrhage
Proven cerebral embolism caused by tumor, Brain Trauma, cerebral parasitic disease, dysbolismus, fibrillation atrial resulted from rheumatic heart disease, coronary heart disease, and other heart diseases
Clinical signs of infection on admission
Pregnant or breast-feeding
Allergic to rhubarb
Preceding or ongoing antibiotic therapy within the last 24 h
Participation in another interventional trial
Immunosuppressant treatment within the last 30 days
Combining severe clinical conditions such as liver, kidney, Hematopoietic System, endocrine system or psychological diseases