Effectiveness of a Bilayering Serum and Cream Containing GABA, DMAE, Cysteamine, and Bakuchiol for Skin Whitening and Anti-Aging

Hasanuddin University

Status and phase: Completed; Phase 2

Conditions: Skin Aging

Treatments: Drug: Bakuchiol; Other: Placebo; Drug: Cysteamine; Drug: DMAE; Drug: GABA

Study type: Interventional

Funder types: Other

Identifiers

NCT07477288

93/UN4.6.4.5.3L / PP36,/ 2025

Details and patient eligibility

About

This study aims to evaluate the clinical efficacy and safety of a multi-functional bilayering skincare regimen-consisting of a serum and cream-for improving skin brightness and reducing wrinkles. The formulation combines four active ingredients: Gamma-Aminobutyric Acid (GABA) 3%, Dimethylaminoethanol (DMAE) 2%, Cysteamine 2.5%, and Bakuchiol 1%. In an 8-week, double-blind, randomized, placebo-controlled trial involving 44 female subjects with Fitzpatrick skin types III-V, investigators will assess changes in skin brightness (L-value), wrinkle scores, pore counts, and melanin/erythema indices using standardized imaging and measurement tools. The primary goal is to determine if this specific combination therapy significantly enhances skin whitening and anti-aging outcomes compared to a placebo.

Enrollment: 44 patients

Sex: Female

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy females aged 30-50 years.

Exclusion criteria

• History of hypersensitivity to GABA, DMAE, Cysteamine, or Bakuchiol.
• Recent facial aesthetic procedures (e.g., laser, chemical peel) within the last 3 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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44 participants in 2 patient groups, including a placebo group

Bilayering Treatment Group

Experimental group

Description:

Participants apply a serum of GABA 3% and DMAE 2% followed by a cream containing Cysteamine 2.5% and Bakuchiol 1% to the face twice daily for 8 weeks. to the face twice daily for 8 weeks.

Treatment:

Drug: GABA

Drug: DMAE

Drug: Cysteamine

Drug: Bakuchiol

Placebo Control Group

Placebo Comparator group

Description:

Participants apply a placebo serum and cream, identical in appearance, fragrance, and texture to the active products but without the active ingredients (GABA, DMAE, Cysteamine, and Bakuchiol), twice daily for 8 weeks

Treatment:

Other: Placebo