Effectiveness of Acetazolamide for Reversal of Metabolic Alkalosis in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients (DIABOLO)

Assistance Publique - Hôpitaux de Paris

Status and phase: Completed; Phase 4

Conditions: Decompensated Chronic Obstructive Pulmonary Disease

Treatments: Drug: Placebo; Drug: Acetazolamide

Study type: Interventional

Funder types: Other

Identifiers

NCT01627639

AOM09109

Details and patient eligibility

About

The purpose of this study is to determine whether acetazolamide are effective to reduce the length of mechanical ventilation in decompensated Chronic Obstructive Pulmonary Disease (COPD) patients developing pure or mixed metabolic alkalosis.

Full description

The purpose of this study is to determine whether acetazolamide is effective to reduce the length of mechanical ventilation in decompensated COPD patients developing pure or mixed metabolic alkalosis.

Enrollment: 380 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Decompensated COPD on invasive mechanical ventilation Less than 24 hours

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

380 participants in 2 patient groups, including a placebo group

Acetazolamide

Active Comparator group

Description:

Acetazolamide (1 g IV per day or 2 g IV per day if coprescription of loop diuretics) or Placebo (saline serum) when pure or mixed metabolic alkalosis being present until planned extubation

Treatment:

Drug: Acetazolamide

Placebo

Placebo Comparator group

Description:

Placebo

Treatment:

Drug: Placebo