Effectiveness of Adhesive Containing MDPB

Radboud University Medical Center

Status: Completed

Conditions: Secondary Caries

Treatments: Drug: Clearfil Protect Bond; Drug: Clearfil SE Bond

Study type: Observational

Funder types: Other

Identifiers

NCT05118100

2021THKHOLL01

Details and patient eligibility

About

9 general practices in the Netherlands were provided with two composite resin adhesives, each for a period of 9 months. One contained MDPB (Adhesive P), and the other one was used as a control (Adhesive S). Patient's age, SES, and caries risk, as well as tooth type/number, reason for restoration placement, used restorative material and bonding agent, and affected surfaces were recorded. All interventions carried out on these teeth in the next 6 years were extracted from the electronic patient records, along with their date, type, reason, and surfaces. Two dependent variables were defined: general failure, and failure due to secondary caries. All data handling and statistical analyses were carried out in R 4.0.5.

Enrollment: 5,102 patients

Sex: All

Ages: 6+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Needing at least one dental restoration

Exclusion criteria

• Opted out of data collection

Trial design

5,102 participants in 2 patient groups

Protect Bond

Description:

Restoration placed using Clearfil Protect Bond adhesive (Kuraray Noritake, Osaka, Japan) , which contains the antibacterial monomer MDPB (12-Methacryloyloxydodecylpyridiniumbromide)

Treatment:

Drug: Clearfil Protect Bond

SE Bond

Description:

Restoration placed using Clearfil SEBond adhesive (Kuraray Noritake, Osaka, Japan)

Treatment:

Drug: Clearfil SE Bond