Effectiveness of Alveolar Bone Preservation in Alveoli With Infectious Process

Universidad de Especialidades Espiritu Santo

Status: Not yet enrolling

Conditions: Alveolar Bone Loss

Treatments: Procedure: alveolar ridge preservation with autologous bone; Procedure: alveolar ridge preservation with bioactive glass

Study type: Interventional

Funder types: Other

Identifiers

NCT06661863

2024-ODONT-002C

Details and patient eligibility

About

Alveolar ridge preservation (ARP) is a surgical technique that aims to minimize the degree of dimensional changes following extraction. In the healing period after extraction, the alveolar bone (AB) undergoes morphological changes during the remodeling process. The changes become evident immediately after tooth extraction, with greater resorption changes observed during the first two months, and these dimensional changes can be observed 1 year after surgery.

Enrollment: 28 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients over 18 years of age
• Patients with indicated tooth extractions
• Patients who have accepted the conditions of the study

Exclusion criteria

• Pregnant patients, breastfeeding or using oral contraceptives
• Smoking patients
• Patients with uncontrolled systemic diseases
• History of autoimmune disease
• Previous traumatic extraction
• Patients taking bisphosphonates or anticoagulants
• Patients who are or have undergone chemotherapy and radiotherapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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28 participants in 2 patient groups

autologous bone

Active Comparator group

Description:

An autologous bone graft is defined as a living tissue capable of promoting bone healing by transferring that tissue from a donor area to a recipient area. It has been defined as the "gold standard" for having the capacity for osteogenesis, osteoinduction, osteoconduction and providing good structural support, showing high biocompatibility and low immunogenicity, however, autologous bone is limited and has greater morbidity due to the collection of autologous bone from the donor site, increased surgical time, greater infection, inflammation, pain and bleeding.

Treatment:

Procedure: alveolar ridge preservation with autologous bone

Bioactive glass

Experimental group

Description:

Bioactive glasses (VB) are a group of synthetic ceramics based on silicates coupled with other minerals. Desirable properties of VB include good biocompatibility, osteoconductivity, antimicrobial activity and a porous structure that promotes vascularization

Treatment:

Procedure: alveolar ridge preservation with bioactive glass