Effectiveness of Analgesia in Total Knee Arthroplasty (ATR-2011)

Jose Antonio Bernia Gil

Status and phase: Completed; Phase 4

Conditions: Pain

Treatments: Drug: morphine ,ketorolac; Drug: ropivacaine,morphine chloride,epinephrine,ketorolac; Drug: ropivacaine; Drug: several drugs: morphine chloride,ropivacaine,epinephrine,ketorolac

Study type: Interventional

Funder types: Other

Identifiers

NCT01304212

ATR-2011

Details and patient eligibility

About

The purpose of this study is to compare the analgesic effectiveness of three techniques: the femoral nerve block, intraarticular infiltration or a combination of both in the control of pain in total knee arthroplasty (KA). The hypothesis to be tested in this study is that the performance multimodal postoperative pain KA combining two analgesic techniques to obtain better analgesia than when applied separately.

Enrollment: 137 patients

Sex: All

Ages: 66+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• intervention program for total knee arthroplasty
• ASA I, II, III
• over 65 years old

Exclusion criteria

• ASA > III
• patients who refuse the realization of technical loco-regional anesthesia
• presence of coagulopathy or impaired hemostatic function
• BMI > 35
• Serious intraoperative complications
• patients undergoing bypass and aortic-femoral or femoro popliteal bypass operated leg
• patients treated for chronic pain diagnosed processes, different knee osteoarthritis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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137 participants in 3 patient groups

femoral block

Active Comparator group

Treatment:

Drug: ropivacaine

local infiltration + femoral nerve block

Experimental group

Description:

Combination of local infiltration with drugs and femoral nerve block

Treatment:

Drug: morphine ,ketorolac

several drugs local infiltration

Active Comparator group

Treatment:

Drug: several drugs: morphine chloride,ropivacaine,epinephrine,ketorolac

Drug: ropivacaine,morphine chloride,epinephrine,ketorolac