Effectiveness of Asiaticoside as Intracanal Medication on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis

Mansoura University

Status and phase: Enrolling; Phase 3; Phase 2

Conditions: Intracanal Medication

Treatments: Drug: Asiaticoside Intracanal medication; Drug: Leddermix Intracanal medication; Drug: Calcium Hydroxide Intracanal medication

Study type: Interventional

Funder types: Other

Identifiers

NCT06566508

A0209023RC

Details and patient eligibility

About

The objective of this study is to investigate "clinically" the effectiveness of Asiaticoside based intracanal medication compared to the commonly used intracanal medicaments (calcium hydroxide Ca(OH)2 and Ledermix) on the levels of bacteria and inflammatory cytokines in root canals and periradicular tissues of teeth with apical periodontitis.

Full description

This study investigate "clinically" the effectiveness of Asiaticoside based intracanal medication compared to the commonly used intracanal medicaments (calcium hydroxide Ca(OH)2 and Ledermix) on the levels of bacteria and inflammatory cytokines in root canals and periradicular tissues of teeth with apical periodontitis.

Enrollment: 36 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Single-rooted with pulp necrosis and apical periodontitis.

Exclusion criteria

Receiving antibiotic treatment within the preceding 3 months.

• Reporting systemic disease.
• Teeth that could not be isolated with rubber dam.
• Teeth with periodontal pockets deeper than 3 mm.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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36 participants in 3 patient groups

Calcium Hydroxide

Active Comparator group

Description:

Intracanal medication

Treatment:

Drug: Calcium Hydroxide Intracanal medication

Leddermix

Active Comparator group

Description:

Intracanal medication

Treatment:

Drug: Leddermix Intracanal medication

Asiaticoside

Active Comparator group

Description:

Intracanal medication

Treatment:

Drug: Asiaticoside Intracanal medication