Effectiveness of Aspirin in Compare With Heparin Plus Aspirin in Recurrent Pregnancy Loss Treatment

Yazd Medical University

Status: Completed

Conditions: Recurrent Pregnancy Loss

Study type: Observational

Funder types: Other

Identifiers

NCT01542411

2362

Details and patient eligibility

About

This study evaluated the effect of anticoagulant treatment on the live-birth rate in women with a history of at least two continuous unexplained miscarriages or thrombophilia. It also compared two methods of treatment with aspirin and aspirin plus heparin.

Enrollment: 520 patients

Sex: Female

Ages: 19 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• unexplained recurrent miscarriage,
• women had previous venous or arterial thromboembolism or who were heterozygous or homozygous for mutations for FV Leiden G1691A, prothrombin gene G20210A (FII G20210A), and methyltetrahydrofolate reductase C677T (MTHFR C677T)

Exclusion criteria

• abnormal karyotypes of both partners,
• uterine and cervical anatomical disorders on pelvic ultrasonography or hysteroscopy,
• abnormal ovaries and abnormal endocrine tests.

Trial design

520 participants in 3 patient groups

recurrent pregnancy loss

thrombophilia, aspirin

heparin