Effectiveness of Bisacodyl Suppository Agent for Dose Reduction of Low Dose PEG

Samsung Medical Center

Status: Completed

Conditions: Bowel Preparation

Treatments: Drug: 1L PEG-Asc; Drug: Bisacodyl 10Mg Suppository; Drug: 2L PEG-Asc

Study type: Interventional

Funder types: Other

Identifiers

NCT03849196

2017-05-100

Details and patient eligibility

About

Proper bowel cleansing before colonoscopy is an important factor to increase the detection rate of lesions. Low volume polyethylene glycol (PEG) plus ascorbic (PEG-Asc) has reduced the dosage of previous bowel preparation agent, but it still presents discomfort to patients. The aim of this study was to confirm the efficacy and convenience of volume reduction of PEG-Asc by adding bisacodyl suppository at the same day by compared with conventional 2L PEG-Asc.

Full description

Eligibility criteria: outpatients between the ages of 20 and 70 years, who were scheduled for colonoscopy between August 2017 and January 2018

Exclusion criteria: patients with a history of gastrointestinal tract surgery, inflammatory bowel disease, severe active colitis, underlying chronic kidney disease, or pregnancy.

Outcome measures: the Boston Bowel Preparation Scale (BBPS)

Enrollment: 168 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• outpatients who were scheduled for colonoscopy between August 2017 and January 2018

Exclusion criteria

• History of gastrointestinal tract surgery
• History of inflammatory bowel disease
• History of severe active colitis
• History of chronic kidney disease
• pregnant woman.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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168 participants in 2 patient groups

2L PEG-Asc

Experimental group

Description:

2L PEG-Asc for bowel preparation

Treatment:

Drug: 2L PEG-Asc

1L PEG-Asc & 'Bisacodyl 10Mg Suppository

Active Comparator group

Description:

1L PEG-Asc with 'Bisacodyl 10Mg Suppository for bowel preparation

Treatment:

Drug: Bisacodyl 10Mg Suppository

Drug: 1L PEG-Asc