Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients

Mahidol University

Status and phase: Completed; Phase 3

Conditions: Antibiotic Resistant Infection

Treatments: Drug: Soap; Drug: 2% chlorhexidine wipe

Study type: Interventional

Funder types: Other

Identifiers

NCT01989416

567-2556-EC4

Details and patient eligibility

About

The purpose of this study is to determine 2% chlorhexidine wipes are effective in preventing of colonization of multi-drug resistant bacteria in intensive care unit patients.

Full description

The purpose of this study is to evaluate the usefulness of bathing with chlorhexidine wipe to reduce the risks of multidrug resistant bacteria acquisition and hospital-acquired bloodstream infection among ICU patients

Enrollment: 481 patients

Sex: All

Ages: 18 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Admission in critical care unit eg. ICU, respiratory care unit, Cardiac care unit with in 24 hours
• Expected duration of critical care unit admission > 48 hours

Exclusion criteria

• History of chlorhexidine allergy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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481 participants in 2 patient groups, including a placebo group

Soap bathing

Placebo Comparator group

Description:

ICU patients will be bathing with soap at least once daily

Treatment:

Drug: Soap

2% chlorhexidine wipes

Experimental group

Description:

Use 2% chlorhexidine wipes to clean the patient at least once daily

Treatment:

Drug: 2% chlorhexidine wipe