Effectiveness of Dental Brushing for Preventing Ventilator-Associated Pneumonia (RASPALL)

Hospital Universitari Joan XXIII de Tarragona.

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Ventilator-Associated Pneumonia; Nosocomial Pneumonia; Pneumonia

Treatments: Procedure: Toothbrushing

Study type: Interventional

Funder types: Other

Identifiers

NCT00842478

FIS 06/0060

Details and patient eligibility

About

Poor oral hygiene is associated with respiratory pathogen colonization and secondary lung infection.The possible association between oral care and incidence of VAP, and the role of dental plaque, mouth and tracheal colonization have not been firmly established. The investigators' hypothesis was that improving oral care with electrical toothbrushing might be effective in reducing the incidence of VAP.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult intubated patients
• Without evidence of pulmonary infection (randomized within 12h of intubation if they were expected to remain ventilated for longer than 48 hours)

Exclusion criteria

• Absence of dental pieces
• Current diagnosis of pneumonia or massive bronchoaspiration
• Tracheostomy (or expected within 48 hours)
• Chlorhexidine allergy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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400 participants in 2 patient groups

Raspall

Experimental group

Treatment:

Procedure: Toothbrushing

Control

No Intervention group