Effectiveness of E-prf Alone and in Combination With Bioactive Glass Nanoparticles in Grade II Furcation Defects

Merna Nasser Mohamed Mostafa Ibrahim Elnahas

Status: Completed

Conditions: Furcation Defects

Treatments: Procedure: Group III (bioactive glass nanoparticles and covered by a collagen membrane); Procedure: Group II (bioactive glass nanoparticles mixed with extended platelet-rich fibrin); Procedure: Group I (extended platelet-rich fibrin)

Study type: Interventional

Funder types: Other

Identifiers

NCT07042204

A03011023OM

Details and patient eligibility

About

The aim of the study is to evaluate and compare the effectiveness of extended platelet-rich fibrin (ePRF) alone and in combination with bioactive glass nanoparticles in the treatment of grade II furcation defects clinically and radiographically.

Full description

A total of 30 grade II furcation defects will be randomly divided into three groups as follows:

Group I: 10 grade II furcation defects will be treated by extended platelet-rich fibrin (ePRF) alone.

Group II: 10 grade II furcation defects will be treated by bioactive glass nanoparticles mixed with extended platelet-rich fibrin (BGn+ePRF).

Group III: 10 grade II furcation defects will be treated by bioactive glass nanoparticles with collagen membrane.

Enrollment: 30 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Presence of Glickman's grade II furcation defects in molars probing depth (PD) ≥5 mm horizontal PD ≥3 mm.
• The patients are in good systemic health and had not undergone any periodontal surgery in the areas to be treated within the prior 12 months.

Exclusion criteria

• Smokers and tobacco chewers.
• Patients that take any medications within the past 6 months that could alter their periodontal status.
• pregnant or lactating females.
• Patients with known allergy to materials or drugs that will be used or prescribed in this study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 3 patient groups

Group I

Experimental group

Description:

10 grade II furcation defects will be treated by extended platelet-rich fibrin (ePRF) alone.

Treatment:

Procedure: Group I (extended platelet-rich fibrin)

Group II

Experimental group

Description:

10 grade II furcation defects will be treated by bioactive glass nanoparticles mixed with extended platelet-rich fibrin (BGn+ePRF).

Treatment:

Procedure: Group II (bioactive glass nanoparticles mixed with extended platelet-rich fibrin)

Group III

Active Comparator group

Description:

10 grade II furcation defects will be treated by bioactive glass nanoparticles with collagen membrane.

Treatment:

Procedure: Group III (bioactive glass nanoparticles and covered by a collagen membrane)