Effectiveness of Hydrolyzed Collagen Peptide Injection for the Treatment of Collateral Ligament Pain

Tiss'You

Status: Completed

Conditions: Collateral Ligament Injury of Stifle Joint

Treatments: Device: Arthrys (Collagen Peptide solution); Drug: Depo medrol

Study type: Interventional

Funder types: Industry

Identifiers

NCT05971004

Collagen Peptide Ligament

Details and patient eligibility

About

Conducted by Binh Luu Thi, Lan Tran Thi, and Minh Hang Hoang Thi at Thai Nguyen National Hospital, the study investigates a new approach to treating persistent collateral ligament pain, common among athletes. The research examines the therapeutic use of hydrolyzed collagen peptide injections, a treatment that addresses pain and inflammation in ways previous methods have not.

The study involves a randomized controlled trial with 62 patients, all diagnosed with inflammation in the collateral ligament site. The patients are split into two groups: one receiving collagen injections alongside oral painkillers and the other receiving depo-medrol injections with oral painkillers.

Enrollment: 62 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age above 18 years,
• lateral knee pain with a duration of 3 months or longer,
• ultrasound evidence of inflammation of the femoral condyle attachment point,
• agreement to participate in the study

Exclusion criteria

• trauma,
• infection,
• dermatitis at the site of the inflammation,
• damage to surrounding knee structures,
• history of chronic inflammatory arthritis (such as gout or rheumatoid arthritis),
• local corticosteroid injection within 3 months before participating in the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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62 participants in 2 patient groups

Collagen Peptide Group

Experimental group

Description:

The Collagen Peptide Group (31 patients) received oral pain relievers (paracetamol and anti-inflammatory NSAIDs) for 3-7 days (if the pain was severe) and one injection of collagen peptide solution (Tiss'You, Republic of San Marino) at the site of the inflamed ligament attachment point (femoral condyle).

Treatment:

Device: Arthrys (Collagen Peptide solution)

Cortison Group

Active Comparator group

Description:

The Cortison Group (31 patients) received oral painkillers (paracetamol and anti-inflammatory NSAIDs) for 3-7 days (if the pain was severe) and one injection of depo-medrol at the site of inflamed ligament attachment point (femoral condyle), combined with oral slow-acting symptomatic drugs (glucosamine 1500mg, atrodar 50mg) for 3 consecutive months.

Treatment:

Drug: Depo medrol