Effectiveness of Individualized Homeopathic Treatment in Perennial Allergic Rhinitis

University of Sao Paulo

Status and phase: Completed; Phase 4

Conditions: Rhinitis

Treatments: Drug: placebo; Drug: homeopathic medicine

Study type: Interventional

Funder types: Other

Identifiers

NCT00822406

[e-mail]

Details and patient eligibility

About

A total of 41 adults with perennial allergic rhinitis were enrolled in a first double-blind placebo-controlled phase for six months, and treated on a weekly basis with sublingual doses of single individualized homeopathic medicines or placebo. After this closed initial phase, all patients were invited to participate in an long-term open-label controlled phase, in that they would receive homeopathic treatment for the maximum period of 36 months, and the results were compared with the improvement of initial phase. Signs and symptoms scores, rescue medication requirements and quality of life were assessed by questionnaires and personal clinical evaluation by a same independent researcher, before and after each phase. Primary and secondary clinical outcome were, respectively, specific and general allergic signs and symptoms scores. Total IgE titles were performed before and after each phase.

Enrollment: 41 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• moderate rhinitis
• to assign written informed consent

Exclusion criteria

• other chronic diseases
• corticosteroid use
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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41 participants in 2 patient groups, including a placebo group

1

Active Comparator group

Description:

This arm received individualized homeopathic medicine during 6 months (initial phase), and completed three years (second phase)

Treatment:

Drug: homeopathic medicine

2

Placebo Comparator group

Description:

This arm received placebo during 6 months. After this period, all patients received individualized homeopathic medicine for three years.

Treatment:

Drug: homeopathic medicine

Drug: placebo