Effectiveness of Intratympanic Dexamethasone With Ligmocaine for Alleviation of Tinnitus

Combined Military Hospital, Pakistan

Status and phase: Unknown; Phase 4

Conditions: Tinnitus

Treatments: Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT04798391

CMHQ

Details and patient eligibility

About

Objective: To determine the effectiveness of Intratympanic dexamethasone with lignocaine in control of idiopathic tinnitus.

Methodology: 264 consenting patients with idiopathic unilateral tinnitus presenting at ENT Department were assessed for tinnitus severity using Modified Tinnitus Handicap Inventory and the scores recorded and subsequently administered intratympanically 2.0 ml (milliliter's) of dexamethasone and lignocaine (1.5 ml dexamethasone + 0.5 ml 1% lignocaine). The dose was repeated twice at weekly intervals. All patients were re assessed on Modified Tinnitus Handicap Inventory two weeks after third Intratympanic administration.

Enrollment: 264 estimated patients

Sex: All

Ages: 19 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• score 20 or above on modified tinnitus handicap inventory

Exclusion criteria

• head trauma, tympanic membrane perforation, depression, ear surgery

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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264 participants in 1 patient group

Dexamethasone with lignocaine

Experimental group

Treatment:

Drug: Dexamethasone