Effectiveness of Low -Versus High -Volume High -Intensity Interval Training in Patients With Chronic Heart Failure

Cairo University (CU)

Status: Enrolling

Conditions: Chronic Heart Failure

Treatments: Drug: Standard medical treatment; Other: High volume high intensity interval training; Other: low-volume high intensity interval training

Study type: Interventional

Funder types: Other

Identifiers

NCT07325942

P.T.REC/012/005825

Details and patient eligibility

About

this study aims to investigate the effect of low vs high volume- high intensity interval training on functional capacity and quality of life in chronic heart failure patients

Enrollment: 45 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Chronic stable heart failure patient with reduced ejection fraction (EF <40)
2. Age Above 18 years old
3. Both males and females
4. The ability to provide informed consent

Exclusion criteria

1. Based on the Scientific Statement from the American Heart Association: contraindications for exercise Testing and Training. (Fletcher et al., 2013)

   1. Acute myocardial infarction (MI), within 2 days
   2. Ongoing unstable angina
   3. Uncontrolled cardiac tachy or brady arrhythmia with hemodynamic compromise
   4. Active endocarditis
   5. Symptomatic severe aortic stenosis
   6. Decompensated heart failure
   7. Acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis
   8. Acute myocarditis or pericarditis
   9. Acute aortic dissection
   10. Physical disability that precludes safe and adequate testing or training
   11. Known obstructive left main coronary artery stenosis
   12. Hypertrophic obstructive cardiomyopathy with severe resting gradient
   13. Recent stroke or transient ischemic attack
   14. Mental impairment with limited ability to cooperate
   15. Resting hypertension with systolic or diastolic blood pressures >200/110 mmHg
   16. Uncorrected medical conditions, such as significant anemia, important electrolyte imbalance, and hyperthyroidism

2. Acute decompensated heart failure NYHA class IV

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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45 participants in 3 patient groups

Low volume high intensity interval training

Experimental group

Description:

This group will receive the usual care (standard medical treatment) in addition to LV-HIIT on a treadmill for 8 weeks, 2 sessions per week.

Treatment:

Other: low-volume high intensity interval training

Drug: Standard medical treatment

high volume high intensity interval training

Experimental group

Description:

In this group, the patients will receive the usual care (standard treatment) in addition to HV-HIIT on a treadmill for 8 weeks, 2 sessions per week

Treatment:

Other: High volume high intensity interval training

Drug: Standard medical treatment

control group

Other group

Description:

It includes 15 patients who will receive standard medical treatment only

Treatment:

Drug: Standard medical treatment