Effectiveness of Pramipexole for Treatment-Resistant Depression

Mass General Brigham

Status and phase

Completed

Phase 4

Conditions

Depression

Treatments

Drug: Placebo

Drug: Pramipexole (Mirapex)

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00231959

DATR AK-TNGP1

K23MH067060 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study will evaluate the effectiveness of pramipexole (Mirapex) in managing treatment-resistant depression.

Full description

Depression is a serious medical illness, for which various types of treatment have been developed. Both medications and therapies have proven effective in treating depression. However, some people with depression do not benefit from these treatments. New medications are needed for treating depression in those who have not responded to commonly used antidepressants. Pramipexole (Mirapex) is most often used for the treatment of Parkinson's disease, but has been reported to have antidepressant effects as well. This study will evaluate the effectiveness of pramipexole in treating depression in individuals that have not responded to other medications.

Participants in this double blind study will be randomly assigned to receive either pramipexole or placebo, in addition to their current medications, for 8 weeks. Treatment response will be assessed at the end of this phase by measuring symptoms of depression. At this time, those individuals who have responded to treatment will have the option to continue in a 6-month follow-up study. Participants will be seen monthly throughout the 6 months to assess treatment response. Participants who do not exhibit a response to treatment will be tapered off the medication. All participants will receive 3 months of follow-up care, regardless of their response to the medication.

Enrollment

65 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Meets diagnostic criteria for major depressive disorder
Meets criteria for current major depressive episode
Score of at least 18 on the Montgomery-Asberg Depression Rating Scale (MADRS) at the baseline visit
Currently being treated with antidepressant monotherapy at an adequate dose for 6 weeks or willing to enter open lead-in treatment
Agrees to use an effective form of contraception throughout the study

Exclusion criteria

Pregnant
At risk for suicide or homicide
Unstable medical illness (e.g., cardiovascular, liver, kidney, respiratory, endocrine, or neurologic disease, including uncontrolled seizure disorder)
History of a substance use disorder within 6 months of study enrollment
History of or current psychotic features
Currently being treated with typical or atypical antipsychotic medications
Currently being treated with a medication known to significantly decrease pramipexole clearance (e.g., cimetidine, ranitidine, diltazem, verapamil, quinine or triamterene)
Clinical or laboratory evidence of untreated hypothyroidism
History of a 2-week or longer course of pramipexole
Intolerance of pramipexole at any dose
Any investigational psychotropic drug use within the last three months
Level 3 or greater antidepressant resistance as assessed by the ATHF
Three or more episodes of self-harm in the year prior to study enrollment
Documented history of poor treatment adherence or frequently missed appointments
Parkinson's disease