Effectiveness of Qufeng Shengshi Fang on Treatment of Allergic Rhinitis.

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: Rhinitis, Allergic, Perennial

Treatments: Drug: Qufeng Shengshi Fang and Loratadine; Drug: Loratadine

Study type: Interventional

Funder types: Other

Identifiers

NCT02653339

JS-958

Details and patient eligibility

About

This is a controlled clinical trials about traditional Chinese medicine named Qufeng Shengshi Fang，which consisted of cicada slough，bombyx batryticatus，radix angelicae，radix sileris，honeysuckle flower，forsythia，lithospermum and radix glycyrrhizae，and Loratadine on treatment of Allergic Rhinitis.There are 180 Patients with allergic rhinitis recruited from Department of Allergy and Traditional Chinese.To carry on statistical analysis of the result of the self and between-group cross-reference by two questionnaires filled before and after treatment.

Enrollment: 180 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• meet allergic rhinitis (include allergic rhinitis with asthma) diagnostic criteria at Peking Union Medical College Hospital Department of Allergy;
• have allergic rhinitis in episodes.
• without antihistamine,local anaesthetic or traditional Chinese medicine in last months.
• signed the informed consent form.

Exclusion criteria

• have severe deviation of nasal septum and nasal polyps.
• have nasal surgery or a history of cancer(tumor).
• have other serious illness or evidence of mental disorders.
• female in pregnancy and lactation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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180 participants in 2 patient groups

Qufeng Shengshi Fang and Loratadine

Experimental group

Description:

Qufeng Shengshi Fang is a traditional Chinese medicine form 8 kinds of herbs. Loratadine is the second generation antihistamines, after converted into its active metabolite Carrie period (carebastine), its antihistamines and allergy effect has been demonstrated in vitro and in vivo tests, also received data from clinical trials.

Treatment:

Drug: Qufeng Shengshi Fang and Loratadine

Drug: Loratadine

Loratadine

Active Comparator group

Description:

Loratadine (INN) is a second-generation H1 histamine antagonist drug used to treat allergies. In structure, it is closely related to tricyclic antidepressants, such as imipramine, and is distantly related to the atypical antipsychotic quetiapine.Loratadine is marketed by Schering-Plough\[needs update\] under several trade names (e.g., Claritin) and also by Shionogi in Japan. It is available as a generic drug and is marketed for its nonsedating properties. In a version named Claritin-D or Clarinase, it is combined with pseudoephedrine, a decongestant; this makes it useful for colds, as well as allergies but adds potential side effects of insomnia, anxiety, and nervousness.

Treatment:

Drug: Qufeng Shengshi Fang and Loratadine

Drug: Loratadine