Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular Response

Police General Hospital, Thailand

Status and phase: Completed; Phase 4

Conditions: Atrial Fibrillation

Treatments: Drug: Amiodarone

Study type: Interventional

Funder types: Other

Identifiers

NCT06262932

RADS regimen

Details and patient eligibility

About

The goal of this clinical trial is to compare in atrial fibrillation patient with rapid ventricular response. The main question it aims to answer are Effectiveness of Repeated Amiodarone dosing regimen versus standard dosing regimen in Atrial fibrillation patient with rapid ventricular response Participants will receive Amiodarone iv treatment with different regimen

• Repeated dosing regimen
• Standard dosing regimen

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age above 18 years old
• Atrial fibrillation with rapid ventricular response patient (ventricular rate > 110)

Exclusion criteria

• Baseline EKG Corrected QT interval (QTc) < 500 msec
• History of pulmonary fibrosis
• History of Cirrhosis
• Cardiac Index <2.2 L/min/m2 or Cardiogenic shock
• Unstable arrhythmia
• Receive amiodarone within 3 months prior to present illness
• Pregnancy
• Amiodarone or Iodine allergy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

Repeated amiodarone bolus dosing regimen

Active Comparator group

Description:

An Initial 150 mg IV amiodarone bolus should be given over a 15-minute period. If the heart rate is still over 110 minutes after the initial treatment, provide an additional 150 mg IV amiodarone bolus over a 15-minute period. During the first 24 hours, this bolus may be administered up to three times in total. Within 24 hours of finishing the first bolus dosage, 900 mg of amiodarone will be administered intravenously.

Treatment:

Drug: Amiodarone

Standard dosing regimen

Active Comparator group

Description:

An Initial 150 mg IV amiodarone bolus should be given over a 15-minute period, then a 24-hour amiodarone loading infusion 900 mg over 24 hours

Treatment:

Drug: Amiodarone