Effectiveness of Rotavirus Immunization in Nicaragua

Sylvia Becker-Dreps

Status: Completed

Conditions: Diarrhea

Study type: Observational

Funder types: Other; Industry; NIH

Identifiers

NCT01133808

09-0371

K01TW008401-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of the investigators study is to compare the rates of childhood diarrhea at the community level before and after the rotavirus vaccination program in León, Nicaragua. From preliminary studies, the investigators anticipate about a 28% reduction in diarrhea following the vaccination program among children who received the vaccine, and a smaller reduction in diarrhea among children who did not receive the vaccine, due to the effects of "herd immunity". In addition, the investigators will collect stool samples from children who develop diarrhea in order determine the etiology of childhood diarrhea in the post-rotavirus immunization era.

Enrollment: 667 patients

Sex: All

Ages: Under 5 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age under 5 years, inclusion in health and demographic surveillance system (CIDS) in Leon, Nicaragua

Exclusion criteria

• Parents do not consent to child's participation