Effectiveness of Thyme in the Management of Clinical Symptoms in Patients with Irritable Bowel Syndrome

Shahid Beheshti University of Medical Sciences

Status: Not yet enrolling

Conditions: Irritable Bowel Syndrome (IBS)

Treatments: Other: Placebo; Dietary Supplement: Thyme extract

Study type: Interventional

Funder types: Other

Identifiers

NCT06609746

IR.SBMU.RETECH.REC.1399.1034

Details and patient eligibility

About

The goal of this clinical trial is to learn if thyme supplement enhances the effects of a low FODAMP diet on reducing clinical symptoms and improving the quality of life of patients with irritable bowel syndrome or not.

The main questions it aims to answer are:

1. Does consumption of thyme reduce the severity score of clinical symptoms in patients with irritable bowel syndrome?
2. Does consumption of thyme increase the quality of life score in patients with irritable bowel syndrome? Researchers will compare thyme supplementation with placebo to see if thyme supplement enhances the effects of a low FODAMP diet on clinical symptoms and quality of life in patients with irritable bowel syndrome.

Participants will:

1. Receive thyme supplement plus a low FODMAP diet or placebo with low FODMAP diet for 8 weeks.
2. Recorde 3 days (1weekend and 2 workday) dietary recalls at week 4 and week 8 to assess adherence to the low FODMP diet.
3. Visit the clinic at the beginning of the study and the end of the study for a check-up and score record

Enrollment: 52 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ages 18-65;
• Patients with irritable bowel syndrome;
• Body Mass Index in the range of 18-25 kg/m2

Exclusion criteria

• Any organic intestinal disease;
• Medical history of chronic gastrointestinal and colorectal disease;
• Any major bowel surgery;
• Medical history of liver and kidney disorders;
• Regular use of laxative, anti-diarrhea and anti inflammatory medications.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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52 participants in 2 patient groups, including a placebo group

Thyme

Experimental group

Description:

Taking thyme extract capsules with a low FODMAP diet

Treatment:

Dietary Supplement: Thyme extract

placebo

Placebo Comparator group

Description:

Taking placebo capsules with a low FODMAP diet

Treatment:

Other: Placebo