Effectiveness of Ultra-low-dose Chest CT With AI Based Denoising Solution

Intermed Hospital

Status: Unknown

Conditions: Lung Diseases

Treatments: Other: Artificial Intelligence based model; Radiation: Underwent ultra dose chest CT; Radiation: Low radiation dose CT

Study type: Interventional

Funder types: Other

Identifiers

NCT05398887

IMC20220515-01

Details and patient eligibility

About

The main objective of the study is to evaluate the detection rate of pulmonary conditions, percentage of ionizing radiation dose reduction, and state of image quality of ULDCT coupling with innovative vendor-neutral CT denoising solution based on deep learning technology.

Full description

Considering lung cancer-related public health challenges, a reliable lung cancer screening method for high-risk cohorts in Mongolia is needed. Thus, our study aims to assess the detection rate of pulmonary conditions, percentage of ionizing radiation dose reduction, and state of image quality of ULDCT coupling with artificial intelligence based CT denoising technique among various patient groups.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged over 18-year-old
• Patients undergoing CT Chest for all purpose

Exclusion criteria

• Age less than 18 years
• Any suspicion of pregnancy
• History of thoracic surgery or placement of the metallic device in the thorax
• An inability to hold respiration during CT

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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200 participants in 2 patient groups

Low dose Chest CT scan

Active Comparator group

Description:

Underwent low dose chest CT with 30% lower radiation dose Interventions: Radiation: Low radiation dose CT Other: Image quality analysis

Treatment:

Radiation: Low radiation dose CT

Ultra low dose CT scan with Artificial Intelligence

Experimental group

Description:

Interventions: Radiation: Low radiation dose CT Image quality Other: Deep-learning based contrast boosting algorithms

Treatment:

Radiation: Underwent ultra dose chest CT

Other: Artificial Intelligence based model