Effectiveness of Vancomycin Loading Therapy

Samsung Medical Center

Status: Completed

Conditions: Infection

Treatments: Drug: Vancomycin HCL

Study type: Interventional

Funder types: Other

Identifiers

NCT01623817

2011-09-067

Details and patient eligibility

About

The goal of tish clinical research study is to identify that loading of vancomycin can facilitate rapid attainment of target trough serum vancomycin concentration.

Full description

The Study drug

• Vancomycin : a glycopeptide antibiotic, is the first line agent in the treatment of methicillin resistant staphylococcus aureus

Study design : Randomized controlled trials

Study Drug Administration

• If your doctor believes you are eligible, and you agree to take part in this study, you will be randomized to two treatment groups.

Enrollment: 20 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Admission to Samsung Medical Center MICU and general wards for infectious diseases and hematology division
• Patients with SIRS (systemic inflammatory response syndrome)
• Intravenous vancomycin therapy deemed necessary

Exclusion criteria

• Age less than 20 years
• Age more than 75 years
• Current renal insufficiency defined as estimated Glomerular filtration rate < 50mg/min/1.73 m2 by MDRD equation
• History of adverse events to vancomycin 5. Pregnant woman

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Vancomcyin, maintain dose

No Intervention group

Description:

This arm is received only maintain dose of vancomycin (15mg/kg twice a day or 1g twice a day).

Vancomycin loading

Experimental group

Description:

This group is received loading dose 30mg/kg. Subsequent doses of vancomycin are considered standard of care.

Treatment:

Drug: Vancomycin HCL