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Effectivity and Safety of Endoscopic Ultrasonography-guided Laser Ablation for Refractory Neoplasms

Zhejiang University logo

Zhejiang University

Status and phase

Unknown
Phase 2
Phase 1

Conditions

Refractory Neoplasms

Treatments

Procedure: EUS-guided laser ablation for refractory neoplasms

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The purpose of this study is to evaluate the safety and efficacy of endoscopic ultrasonography (EUS) guided laser ablation liver, pancreas, and retroperitoneal tumors, the investigators used preoperative and postoperative US/CEUS/CT/MRI to assess lesions, and laboratory tests including the tumor markers to evaluate the general condition of patients. Intraoperative US/CEUS/CT would be applied to monitor ablation lesions.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with refractory neoplasms including small hepatocellular carcinoma adjacent to the gastrointestinal tract, pancreatic neuroendocrine tumor, retroperitoneal tumor with less than 3 cm in diameter;
  • Patients with Child-Pugh A/B;
  • Patients with PLT ≥ 50*10E9/L and PT ≤ 20s.

Exclusion criteria

  • Patients with severe cardiopulmonary disease, intolerant endoscopy and anesthesia, upper gastrointestinal bleeding in shock, corrosive esophagitis and acute gastritis.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

80 participants in 1 patient group

EUS-guided laser ablation for refractory neoplasms
Experimental group
Treatment:
Procedure: EUS-guided laser ablation for refractory neoplasms

Trial contacts and locations

1

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Central trial contact

Tian'an Jiang, Phd; Guo Tian, Master

Data sourced from clinicaltrials.gov

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